Sorted: 0
Stability Wave 1: Homeostasis
Time: 60
Streak: 0
REPAIR
Repair
Fix DNA
APOPTOSIS
Apoptosis
Recycle
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V
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D
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About Mitosis Manager

Sort cells through checkpoints before cancer starts in this free online mitosis game about the cell cycle for biology students.

Mitosis Manager is a free online mitosis game where you sort dividing cells through cell cycle phases and checkpoints before errors pile up into cancer. This cell cycle game makes the most choreographed process in biology your responsibility.

The cell cycle runs G1, S, G2 then M, with checkpoints between each phase acting as quality gates. Cyclins and CDK enzymes push cells forward while checkpoint proteins like p53 halt the line when DNA damage or bad spindle attachments appear. Healthy control means a cell only divides when everything is ready.

Every sorting error in the game mirrors real carcinogenesis. Cells that skip checkpoints accumulate mutations, ignore stop signals and divide without limits, the exact hallmarks of tumors. Cancer therapies like CDK inhibitors work by re-imposing the checkpoint discipline you enforce here, one phase at a time.

Key Science Concepts

What You'll Learn

Grade Level: Middle School, High School

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How to play

  1. Divide Healthy Cells Let healthy cells reach the right DIVIDE zone to produce twin daughter cells.
  2. Sort Damaged Cells Drag or flick damaged cells into the REPAIR or APOPTOSIS bin before they divide!
  3. Recycle Mutants Fast mutated cells cannot be repaired. Throw them into APOPTOSIS immediately!
  4. Tap Power-ups Tap G1 checkpoints, p53 guardians and caspase tokens on belts for massive boosts!

Frequently asked questions

Is Mitosis Manager free to play?
Yes. Mitosis Manager is completely free to play in your browser. There is no download, install or account needed.
What grade level is Mitosis Manager for?
Mitosis Manager is designed for Middle School, High School students and works well as a classroom activity or homework.
Does Mitosis Manager work on phones and tablets?
Yes. Mitosis Manager runs in any modern browser on desktop computers, Chromebooks, tablets and phones in landscape mode.

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